Programme
Combating Resistance: microbes and vectors
2018 Institut Pasteur International Network Symposium
Paris, November 15-16, 2018

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Thursday, November 15, 2018
Opening ceremony
08:30 am-09:00 am
0
08:30 am

Stewart Cole, President, Institut Pasteur


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08:40 am

François-Xavier Weill, Enteric Bacterial Pathogens unit, Institut Pasteur
Helmi Mardassi, Laboratory of Molecular Microbiology, Vaccinology and Biotechnological Development, Institut Pasteur de Tunis


0
08:50 am

Françoise Barré-Sinoussi, 2008 Nobel Prize in Medicine, Honorary President of the Institut Pasteur International Network


Opening Keynote lecture
09:00 am-09:30 am
0
09:00 am

The unfolding of antimicrobial resistance

K. Fukuda
Director and Clinical Professor, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, China 
How does resistance affects global health?
09:30 am-11:00 am
Chairs: Bich-Tram Huynh, Institut Pasteur, France - Anna-Bella Failloux, Institut Pasteur, France
1
09:30 am

Emergence of P. vivax resistance to chloroquine in French Guiana

L. Musset*1, C. Heugas1-2, R. Naldjinan3, D. Blanchet4, P. Houze5, P. Abboud3, B. Volney1, G. Walter3, Y. Lazrek1, L. Epelboin3, S. Pelleau1, P. Ringwald6, E. Legrand7, M. Demar4, F. Djossou3
1Laboratoire de parasitologie, CC OMS pour la surveillance de la résistance aux antipaludiques, CNR Paludisme, Institut Pasteur de la Guyane, Cayenne, French Guiana 2Faculté de médecine, Université de Poitiers, Poitiers, France 3Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana 4Laboratoire Hospitalo-Universitaire de Parasitologie et Mycologie, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana 5Laboratoire de biochimie, Hôpital Saint Louis, Paris, France 6Global Malaria Program, World Health Organization, Geneva, Switzerland 7Malaria genetic and resistance group, Institut Pasteur, Paris, France 
2
09:50 am

Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, risk factors and genomic diversity

B. Huynh*1, V. Passet2, A. Rakotondrasoa3, L. Panunzi2, A. Kerleguer4, A. De Lauzanne5, P. Piola5, P. Herindrainy6, A. Ndir7, T. Diallo3, A. Seck3, E. Delarocque-Astagneau1, D. Guillemot1, L. Borand5, R. Bercion3, M. Vray7, J.M. Collard3, S. Brisse2
1UMR 1181, Institut Pasteur, INSERM, University of Versailles, Saint-Quentin, France 2Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur de Paris, Paris, France 3Experimental bacteriology unit, Institut Pasteur Madagascar, Madagascar, Madagascar 4Medical Biology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia 5Epidemiology & Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia 6Epidemiology & Public Health Unit, Institut Pasteur Madagascar, Madagascar, Madagascar 7Epidemiology & Public Health Unit, Institut Pasteur de Dakar, Dakar, Senegal 8Laboratory of medical biology, Institut Pasteur de Dakar, Dakar, Senegal 
3
10:10 am

Isofemale lines of Aedes aegypti with different levels of resistance to deltamethrin differ in their vector competence for chikungunya virus

L. Wang*1, A. Fontaine2, P. Gaborit1, Y. Epelboin1, I. Dusfour1
1Vector adaptation and control unit, Institut Pasteur de la Guyane, Cayenne, French Guiana 2Unité de Parasitologie et Entomologie, Institut de Recherche Biomédicale des Armées, Marseille, France 
4
10:30 am

Unwanted souvenirs: acquisition and persistence of AMR in the gut microbiome of international travelers visiting endemic areas

J. Penders*1, J. Van Hattem2, M. Arcilla3, B. Vu4-5, H. Wertheim5, R. Van Doorn4, H.H. Tran6, H. Verbrugh3, C. Schultsz2, D. Melles3, M. De Jong2
1Medical Microbiology, Maastricht University Medical Center+, Maastricht, The Netherlands 2Amsterdam University Medical Center, Amsterdam, The Netherlands 3Erasmus Medical Center, Rotterdam, The Netherlands 4Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, Hanoi, Vietnam 5Department of Medical Microbiology, Radboud University, Nijmegen, The Netherlands 6National Institute of Hygiene and Epidemiology, Hanoi, Vietnam 
5
10:50 am

Early life antibiotic exposure and infant gut resistome

H.M. Tun*1-2, MHH. Shum1, TTY. Lam1, A.L. Kozyrskyj2
1School of Public Health, University of Hong Kong, Hong Kong, China 2Department of Pediatrics, University of Alberta, Edmonton, Canada 
6
10:53 am

Is malaria vector control still useful despite insecticide resistance?

H. Alout*1, B. Roche2, R.K. Dabiré3, A. Cohuet4
1UMR ASTRE, INRA/CIRAD, Montpellier Cedex 05, France 2UMMISCO, Institut de Recheche et Développement, Bondy, France 3Institut de Recheche en Sciences de la Santé, Bobo Dioulasso, Burkina Faso 4MIVEGEC, Institut de Recheche et Développement, Montpellier, France 
7
10:56 am

Parasite Clearance and Efficacy of Artesunate + Amodiaquine and Artemether + Lumefantrine in Bouake district Côte d’Ivoire

O.A. Toure*1, N.L. Tiacoh1, S.B. Assi2, A.A. Kone1, E.G. Adji1, A.A. Ako1, B. Coulibaly1, B. Kone3, O. Ouattara3, S. Beourou1, A. Koffi4, F. Remoue5, C. Rogier6
1Parasitology Mycology Department/Malariology unit/, Institut Pasteur, Abidjan, Ivory Coast 22. Institut Pierre Richet/Programme National de Lutte contre le Paludisme, Bouake, Ivory Coast 3Formation Sanitaire Dar-Es-Salam, Bouake, Ivory Coast 44. Institut Pierre Richet, Bouake, Ivory Coast 55. Institut de Recherche pour le Développement. UMR 224-MIVEGEC/IPR, Bouake, Ivory Coast 6Service de Santé des Armées, Paris, France 
Coffee Break
11:00 am-11:30 am
How does resistance affects global health?
11:30 am-01:00 pm
Chairs: Didier Fontenille, Institut Pasteur du Cambodge, Cambodia - Igor Mokrousov, Russia
8
11:30 am

High prevalence of ESBL producing enterobacteriacae fecal carriage within the community in Cambodia: results of the BIRDY and PEEC NIC studies

A. De Lauzanne*1, N. Sreng2, T. Sok3, E. Foucaud1-4, T. Chon1, C. Yem1, V. Hak1, S. Heng5, S. Meng5, M. Nadimpalli6-7, S. Le Hello7, MAN. Rabenandrasana8, J.M. Collard8, M. Gouali2, P. Piola1, A. Kerléguer5, E. Delarocque-Astagneau6-9, B.T. Huynh6-9, L. Borand1, S. Bernabeu10-11, P. Long1, S. Born1, M. Inghammar12, T. Naas10-13
1Epidemiology and Public Health Unit, Pasteur du Cambodge, Institut Pasteur International network, Phnom Penh, Cambodia 2Laboratory of environment and food safety, Institut Pasteur du Cambodge, Institut Pasteur International network, Phnom Penh, Cambodia 3Cambodian Center for Disease Control, former director, Ministry of Health, Phnom Penh, Cambodia 4Pediatric Unit, Hôpital Jean Verdier, AP-HP, Paris, France 5Medical laboratory, Institut Pasteur du Cambodge, Institut Pasteur International network, Phnom Penh, Cambodia 6Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious diseases, Institut Pasteur, Paris, France 7Unité des Bactéries Pathogènes Entériques, Centre National de Référence des E. coli, Shigella et Salmonella, Institut Pasteur, Paris, France 8Experimental Bacteriology Unit, Institut Pasteur De Madagascar, Institut Pasteur International network, Antananarivo, Madagascar 9INSERM, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Paris, France 10Carbapenemase-producing Enterobacteriaceae, Associated French National Reference Center for Antibiotic Resistance, Le Kremlin Bicêtre, France 11Evolution and Ecology of Resistance to Antibiotics Unit, Institut Pasteur, Paris, France 12Department of Clinical Sciences Lund, Section for Infection Medicine, Lund University, Lund, Sweden 13EA7361, Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France 
9
11:50 am

Propensity of Mycobacterium tuberculosis Haarlem genotype to generate successful MDR-TB clones in Northern Tunisia

N. Dekhil*, N. Meftahi, B. Mhenni, H. Mardassi
Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia, Tunis, Tunisia 
10
12:10 pm

Anopheles competence to Artemisinin-resistant Plasmodium falciparum isolates

S. Gangnard1, O. Bomme1, N. Puchot1, N. Gatsi1, C. Andolina2, F. Nosten2, N. White3, A. Dondorp3, C. Bourgouin*1
1Functional Genetics of Infectious Diseases, Institut Pasteur, Paris, France 2Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand 3Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 
11
12:30 pm

Adhesion and biofilm formation by distinct lineages of staphylococcus aureus isolated at Rio de Janeiro hospitals

L. Guimarães1, B. De Souza1, C. Whitaker1, R. Chamon*2-1, R. Hirata Júnior3, R. Ferreira1, K. Dos Santos1
1Departamento de Microbiologia Médica, IMPPG, Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil 2Pathology Dept, Universidade Federal Fluminense, Niteroi, Brazil 3Universidade Estadual do Rio de Janeiro, Rio De Janeiro, Brazil 
12
12:50 pm

Surprizing circulation of Plasmodium vivax parasite in asymptomatic children and hospitalized patients residing in south-eastern Sénégal: Kédougou and Tambacounda

M. Niang1, B. Mbengue2-3, F. Diop1, M.L. Varela1, O. Ka4, A. Sow5-6, K.S. Diop1, A. Dieye2-3, A. Toure1, R. Perraut*1, *1
1Immunology, Institut Pasteur de Dakar, Dakar, Senegal 2Immunogenetic Unit, Institut Pasteur de Dakar, Dakar, Senegal 3Service d’Immunologie FMPO, Université Cheikh Anta Diop de Dakar, Dakar, Senegal 4Biology Laboratory, Hopital Régional de Tambacounda, Tambacounda, Senegal 5Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal 6dept emerging diseases, West African Health Organization, Ouagadougou, Burkina Faso 
13
12:53 pm

Evidence of insecticide resistance to pyrethroids and bendiocarb in Anopheles funestus populations from Tsararano (Marovoay district), Madagascar

T. Rakotondranaivo*1, M. Randrianarivelojosia2-3, O. Ndiath1
1G4 Malaria group, Institut Pasteur de Madagascar, Antananarivo, Madagascar 2Unité de Recherche sur le Paludisme, Institut Pasteur de Madagascar, Antananarivo, Madagascar 3Faculté des Sciences, Université de Toliara, Toliara, Madagascar 
14
12:56 pm

Increased use of Tenofovir concurs with increased resistance on First line HIV treatment in Cameroon between 2014 and 2016 following the WHO 2013 recommendations

E. Ngo-Malabo, P. Ngoupo*, S. Sadeuh-Mba, L. Ngono, R. Njouom
Virology, Centre Pasteur of Cameroon, Yaounde, Cameroon 
Lunch break & Poster session 1
01:00 pm-02:15 pm
Group Photo
02:15 pm-02:30 pm
Plenary session
02:30 pm-03:30 pm
Chairs: Didier Ménard, Institut Pasteur, France - Sara Eyangoh, Cameroon
0
02:30 pm

Monitoring antiviral drug resistance in resource-limited settings

E. Delaporte
Professor of Tropical Diseases, University of Montpellier, Montpellier, France 
0
03:00 pm

Recent insights into mechanisms of antimalarial drug resistance in Plasmodium falciparum

D. Fidock
C. S. Hamish Young Professor of Microbiology & Immunology, Professor of Medical Sciences, Columbia University Medical Center, New York, United States 
What are the mechanisms of drug resistance?
03:30 pm-05:00 pm
Chairs: Philippe Glaser, Institut Pasteur, France - Soojin Jang, South Korea
15
03:30 pm

Identification of novel DAA-resistant mutations in genotype 2, 3 and 6 hepatitis C virus

J. Zhong
Unit of Viral Hepatitis, Shanghai, China 
16
03:50 pm

Sequence modification of the master regulator Pdr1 interferes with its transcriptional autoregulation and confers altered azole resistance in Candida glabrata

C. Chen
Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 
17
04:10 pm

The L. pneumophila quorum sensing system promotes persister formation in infected A. castellanii

N. Personnic*1, E. Lezan2, B. Striednig1, A. Welin1, A. Schmidt2, H. Hilbi1
1Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland 2Biozentrum, University of Basel, Basel, Switzerland 
18
04:30 pm

Use of isofemale lines to decipher the multiple and cross resistance to insecticides in Aedes aegypti mosquitoes

Y. Epelboin*1, L. Wang1, V. Choumet2, P. Gaborit1, Q. Gianetto3, T. Douché3, A. Guidez1, T. Chaze3, J. Issaly1, M. Matondo3, I. Dusfour1
1Vectopôle Amazonien Emile Abonnenc, Unité Contrôle et adaptation des vecteurs, Institut Pasteur de la Guyane, Cayenne, French Guiana 2Unité Environnement et Risques Infectieux, Institut Pasteur, Paris, France 3Unité de Spectrométrie de Masse Structurale et Protéomique, Institut Pasteur, Paris, France 
19
04:50 pm

Synthetic miRNAs induce dual arboviral-resistance phenotypes in the vector mosquito Aedes aegypti

P.S. Yen*1, A. James2, J.C. Li3, C.H. Chen3, A.B. Failloux1
1Department of Virology, Institut Pasteur, Paris, France 2Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, University of California, Irvine, United States 3National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan 
20
04:53 pm

Global mechanisms of gene expression regulation for bacterial adaptation to sublethal levels of chloramphenicol

Q. Zhang1, E. Brambilla1, R. Li2, H. Shi2, M. Cosentino Lagomarsino3, B. Sclavi*1
1LBPA, UMR 8113, CNRS, ENS Paris-Saclay, Cachan, France 2CAS Key Laboratory of Theoretical Physics, Chinese Academy of Sciences, Beijing, China 3LCQB, UMR 7238, CNRS - Sorbonne Université, Paris, France 
21
04:56 pm

Discovery of Mtb resistance mutations based on screening synthetic mutant libraries

N. Bongaerts*1-2, E. Wintermute1-2, A. Lindner1-2
1Centre de Recherches Interdisciplinaires (CRI), Paris, France 2U1001, INSERM, Paris, France 
Coffee Break
05:00 pm-06:00 pm
Sanofi – Institut Pasteur 2018 Awards
06:00 pm-08:45 pm
Cocktail
08:45 pm-10:00 pm
Friday, November 16, 2018
Robert Deschiens Young Investigator Prize presented by the Exotic Pathologies Society
08:25 am-08:30 am
Plenary session
08:30 am-09:30 am
Chairs: Isabelle Dusfour, Institut Pasteur de la Guyane, French Guiana - Antoine Talarmin, Institut Pasteur de Guadeloupe, France
0
08:30 am

Tackling the challenge of vector resistance

D. Weetman
Senior Lecturer in the Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom 
0
09:00 am

Harnessing biological insight to accelerate the discovery of anti-tuberculosis drugs with new mechanisms of action

V. Mizrahi
Director, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa 
How to combat drug resistance?
09:30 am-11:00 am
Chairs: Lawrence Ayong, Pasteur Center in Cameroon, Cameroon - Halima Boubacar Maïnassara, CERMES, Niger (The)
22
09:30 am

Learning from bacteriophages new ways to overcome antibiotic resistance

M. De Jode*1, A. Chevalllereau1, M. Monot2, E. Brambilla3, G. Karimova4, L. Debarbieux1
1Microbiology, Molecular Biology of Gene in Extremophiles, Interactions Bacteriophages Bacteria in Animals, Institut Pasteur, Paris, France 2Pathogenesis of Bacterial Anaerobes, Microbiology Department, Institut Pasteur, Paris, France 3Microbial Morphogenesis and Growth, Microbiology Department, Institut Pasteur, Paris, France 4Biochemistry of Macromolecular Interactions, Structural Biology and Chemistry Department, Institut Pasteur, Paris, France 
23
09:50 am

Concerted IPIN efforts on Leishmania drug resistance reveal novel mechanisms of parasite genomic adaptation and drive host-directed anti-leishmanial drug discovery

G. Späth
On behalf of the LeiSHield consortium and the International Mixed Unit ‘Inflammation and Leishmania infection’, Institut Pasteur International Network, Paris, France 
24
10:10 am

Development of a HTS based on the essential bacterial Apolipoprotein N-acyltransferase (Lnt) to screen for specific inhibitors using chemical libraries

K. Nozeret1, A. Boucharlat2, F. Agou2, N. Buddelmeijer*1
1Biology and Genetics of the Bacterial Cell Wall Unit, Institut Pasteur, Paris, France 2Chemogenomic and Biological Screening PLatform, C2RT, Institut Pasteur, Paris, France 
25
10:30 am

Circumventing drug resistance in leishmaniasis and trypanosomiasis by target-specific inhibition of the redox metabolism of the pathogens*

D. Benitez1, A. Medeiros2, V.C. Ferrerira3, J.H. No4, C.I. De Oliveira3, C. Kunick4, M. Comini*1
1Lab. Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay 2Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany 3Lab. Immuno-parasitology, Fiocruz Bahia, Salvador, Brazil 4Leishmania Research Lab, Institut Pasteur Korea, Gyeonggi-Do, South Korea 
26
10:50 am

Pheromones to manipulate Aedes aegypti behavior: a new tool for vector control?

A. Boullis*, L. Héry, C. De Graaf, C. Delannay, A. Vega Rua
Vector Control Research Laboratory, Institut Pasteur of Guadeloupe, Les Abymes, France 
27
10:53 am

Awakening Novel Antibiotic Classes from rare Actinomycetes

S. Moureu*1, H. Drobecq2, B. Villemagne3, A. Herledan3, D. Beury4, T. Caradec1, J.M. Saliou5, D. Hot4, N. Willand3, R.C. Hartkoorn1
1Chemical Biology of Antibiotics Team, Centre d’Infection et d’Immunité de Lille, Institut de Biologie de Lille, Institut Pasteur de Lille, INSERM U1019 - CNRS UMR 8204, 1, rue du professeur Calmette, Lille Cedex, France 2Chemical Biology of Flatworms, Centre d’Infection et d’Immunité de Lille, Institut de Biologie de Lille, Institut Pasteur de Lille, INSERM U1019 - CNRS UMR 8204, 1, rue du professeur Calmette, Lille Cedex, France 3Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 – Drugs and Molecules for Living Systems, Lille, France 4Transcriptomics & Applied Genomic, Institut Pasteur de Lille, 1, rue du professeur Calmette, BP 245, Lille Cedex, France 5Plateforme de Protéomique et Peptides Modifiés, Institut Pasteur de Lille, INSERM U1019 - CNRS UMR 8204, Université de Lille, 1, rue du professeur Calmette, Lille Cedex, France 
28
10:56 am

Identification of new antipneumococcal molecules through high throughput screening

H. Kim1, N. Kim2, D. Shum2, S. Huddar3, C. Park3, S. Jang*1
1Antibacterial Resistance Laboratory, Institut Pasteur Korea, Seongnam, South Korea 2Screening Discovery Plateform, Institut Pasteur Korea, Seongnam, South Korea 3Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of chemical Technology, Daejeon, South Korea 4Discovery Biology, Antibiotic Resistance Laboratory, Seongnam, South Korea 
Coffee Break
11:00 am-11:30 am
How to monitor drug resistance and assess the spread of resistant population?
11:30 am-01:00 pm
Chairs: Koussai Dellagi, Institut Pasteur International Network prospective and strategy Officer, Institut Pasteur, France - Lise Musset, French Guiana
29
11:30 am

Rapid increase and northward spread of artemisinin-resistant Plasmodium falciparum in Laos

M. Iwagami*1-2, M. Nakatsu2-3, P. Khattignavong1-3, P. Soundala1-3, S. Keomalaphet1-3, E. Matsumoto-Takahashi2-3, V. Pommelet1, B. Hongvanthong3-4, P.T. Brey3-5, S. Kano2-3
1Parasitology Lab, Institut Pasteur du Laos, Vientiane, Laos 2Department of Tropical Medicine and Malaria, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan 3SATREPS project (JICA/AMED) for Parasitic Diseases, Vientiane, Laos 4Center of Malariology, Parasitology and Entomology, Lao Ministry of Health, Vientiane, Laos 5Institut Pasteur du Laos, Vientiane, Laos 
30
11:50 am

The 2016-2017 Yemen cholera outbreak is caused by a recent seventh pandemic Vibrio cholerae O1 El Tor sublineage with an unexpected antibioresistance profile

F.X. Weill*1, D. Domman2, E. Njamkepo1, A. Almesbahi3, M. Naji3, S. Nasher3, A. Rakesh4, A. Assiri5, N. Sharma6, S. Kariuki7, M. Pourshafie8, J. Rauzier1, A. Abubakar9, J. Carter10, J. Wamala11, C. Seguin12, C. Bouchier13, T. Malliavin14, B. Bakhshi15, H. Abulmaali16, D. Kumar6, S. Njoroge7, M. Malik9, J. Kiiru7, F. Luquero4, A. Azman17, T. Ramamurthy18, N. Thomson2-19, M.L. Quilici*1
1Unité des Bactéries Pathogènes Entériques, Institut Pasteur, Paris, France 2Wellcome Trust Sanger Institute, Hinxton, United Kingdom 3National Centre of Public Health Laboratories, Sana'a, Yemen 4Epicentre, Paris, France 5Ministry of Health, Riyadh, Saudi Arabia 6Maharishi Valmiki Infectious Diseases Hospital, Delhi, India 7Kenya Medical Research Institute, Nairobi, Kenya 8Pasteur Institute of Iran, Tehran, Iran 9EMRO, Cairo, Egypt 10Amref Health Africa, Nairobi, Kenya 11WHO, Juba, Sudan 12MSF, Dubai, United Kingdom 13Institut Pasteur, PF1, Paeis, France 14Institut Pasteur, Unité de Bioinformatique Structurale, Paris, France 15Tarbiat Modares University, Tehran, Iran 16CPHL, Baghdad, Iraq 17Johns Hopkins Bloomberg School of Public Health, Baltimore, United States 18THSTI, Faridabad, India 19London School of Hygiene and Tropical Medicine, London, United States 
31
12:10 pm

City-wide metagenomics uncover antibiotic resistance reservoirs in urban beach and sewage waters

P. Fresia1-2, V. Antelo2, C. Salazar2, M. Giménez1, B. D'alessandro3, G. Gonnet4-2, G. Iraola*1-2
1Unidad de Bioinformática, Institut Pasteur Montevideo, Montevideo, Uruguay 2Proyecto Centro Uruguayo de Metagenómica, Institut Pasteur Montevideo, Montevideo, Uruguay 3Servicio de Evaluación y Control Ambiental, Intendencia Municipal de Montevideo, Montevideo, Uruguay 4Department of Computer Science, ETH Zurich, Zurich, Switzerland 
32
12:30 pm

Genomic taxonomy of microbial strains: Tracking globally emerging resistant sublineages in humans, animals and the environment

J. Guglielmini1, A. Criscuolo1, R. Izdebski2, V. Passet3, K. Jolley4, S. Brisse*3
1Bioinformatics and Biostatistics Hub, C3BI, USR 3756 IP CNRS, Institut Pasteur, Paris, France 2Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland 3Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Paris, France 4Zoology Department, Oxford University, Oxford, United Kingdom 
33
12:50 pm

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi

L. Berná*1, M. Rodriguez2, M.L. Chiribao1-3, A. Parodi-Talice1-4, S. Pita1-4, G. Rijo1, F. Alvarez-Valin2, C. Robello1-3
1Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay 2Sección Biomatemática - Unidad de Genómica Evolutiva, Facultad de Ciencias-UDELAR, Montevideo, Uruguay 3Departamento de Bioquímica, Facultad de Medicina-UDELAR, Montevideo, Uruguay 4Sección Genética, Facultad de Ciencias-UDELAR, Montevideo, Uruguay 
34
12:53 pm

In vitro susceptibility of Cambodian Plasmodium vivax to four antimalarial treatments

C. Roesch*, M. Mairet-Khedim, S. Kim, B. Witkowski, J. Popovici
Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia 
35
12:56 pm

Phenotype and epidemiology of P. falciparum isolates from Cambodia harboring double resistance patterns to piperaquine and mefloquine

M. Mairet-Khedim1-2, S. Topku3-2, N. Khim1-2, R. Leang4, P. Ringwald5, D. Menard6-1, J.C. Barale3-2, B. Witkowski1-2
1Malaria Molecular Epidemiology, Pasteur Institute in Cambodia, Phnom Penh, Cambodia 2Malaria Translational Research Unit, Pasteur Institute, Paris, France 3Biology of Malaria Targets & Antimalarials, Pasteur Institute, Paris, France 4National Center for Malaria Control and Entomology, Phnom Penh, Cambodia 5World Health Organization, Geneva, Switzerland 6Biology of Host-Parasite Interactions, Pasteur Institute, Paris, France 
Lunch break & Poster session 2
01:00 pm-02:00 pm
Plenary session
02:00 pm-03:00 pm
Chairs: Françoise Barré-Sinoussi, - Stewart Cole, Institut Pasteur, France
0
02:00 pm

2018 Dedonder-Clayton Award


0
02:30 pm

Combating antimicrobial resistance of enteric bacteria in resource-limited settings

I. Okeke
Professor at the University of Ibadan, Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria 
How to monitor drug resistance and assess the spread of resistant population?
03:00 pm-04:30 pm
Chairs: François-Xavier Weill, Institut Pasteur, France - Helmi Mardassi, Institut Pasteur de Tunis, Tunisia
36
03:00 pm

Emerging Mycobacterium tuberculosis drug-resistant strain in West Asia: warning of global spread due to refugee flows

I. Mokrousov*1, E. Shitikov2, Y. Skiba3, S. Kolchenko2-4, E. Chernyaeva5, A. Vyazovaya1
1Laboratory of Molecular Epidemiology and Evolutionary Genetics, Institut Pasteur in Saint Petersburg, St. Petersburg, Russia 2Scientific-Clinical Center of Physical-Chemical Medicine, Moscow, Russia 3Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan 4Moscow Institute of Physics and Technology, Dolgoprudny, Russia 5St. Petersburg State University, St. Petersburg, Russia 
37
03:20 pm

Selection and global dissemination of carbapenamase-producing Escherichia coli

R. Patiño-Navarrete*1-2, I. Rosinski-Chupin1-2, L. Gauthier1-3, N. Cabanel1-2, J. Takissian1-3, J.Y. Madec4, R. Bonnin1-3, M. Hamze5, T. Naas1-3, P. Glaser1-2
1Unite EERA, Institut Pasteur,APHP,Université Paris Saclay, Paris, France 2UMR3525, CNRS, Paris, France 3Associated French National Reference Center for Antibiotic Resistance, Bicetre, France 4Agence Nationale de Sécurité Sanitaire (ANSES), Lyon, France 5Ecole Doctorale des Sciences et de Technologie, Faculté de Santé Publique, Université Libanaise, Tripoli, Lebanon 
38
03:40 pm

Risk of developing multi-drug resistance among patients with tuberculosis treatment failure is associated with M. tuberculosis Lineage 1 in Madagascar

E. Meunier1, M.S. Rabodoarivelo1, S. Grandjean Lapierre2-1, M. Raherison3-1, V. Rasolofo1, N. Rakotosamimanana*1
1Mycobacteria Unit, Antananarivo, Madagascar 2Stony brook University, New York, United States 3Direction de la Lutte contre la Tuberculose, Ministère de la Santé Publique de Madagascar, Antananarivo, Madagascar 
39
04:00 pm

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

V. Mathys, D. Hung, A. Baulard, L. Rigouts, J.Y. Coppee, R. Bhattacharyya, A. Van Den Bossche, P. Ceyssens*
Bacterial Diseases, Brussels, Belgium 
40
04:20 pm

Organotypic tissue slice cultures for intracellular susceptibility testing of extracellular pathogens

J. Wanford1, D. Carreno1, D. Grandgirard2, S. Leib2, M. Oggioni*1
1University of Leicester, Leicester, United Kingdom 2University of Bern, Bern, Switzerland 
41
04:23 pm

Mosquito continuous cell line that behaves like neurons: a new tool for high-throughput screening for insecticidal property

J. Gaburro1-2, P. Paradkar1, S. Nahavandi2, A. Bhatti2, J. Duchemin*3-1
1Health and Biosecurity, Commonwealth Scientific and Industrial Research Organization, Geelong, Vic, Australia 2Institute for Intelligent Systems Research and Innovation, Deakin University, Waurn Ponds, Vic, Australia 3Vectopole Amazonien Emile Abonnenc, Cayenne, French Guiana 
42
04:26 pm

Anti-Neisseria drugs screening start revealing the Achilles' heel of N. meningitdis and N. gonorrhoeae.Anti-Neisseria drugs screening start revealing the Achilles' heel of N. meningitdis and N. gonorrhoeae

M. Lebughue1, E. Bernet1, G. Golbaghi2, M. Harich2, A. Castonguay2, F. Veyrier*1
1Bacterial Symbionts Evolution, INRS-Institut Armand Frappier, Laval, Canada 2Chimie, INRS-Institut Armand Frappier, Laval, Canada 
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